http://www.jisciences.com/index.php/journal/issue/feedJournal of Integral Sciences2025-01-29T00:30:31-05:00Editor in Chiefeditor@jisciences.comOpen Journal Systems<p>Journal of Integral Sciences(JIS) is an international, single blind peer-reviewed, open access journal that publish quarterly every year with high-quality papers in the fields of science and technology. These fields include all aspect of: Basic and applied Science (Biology, Molecular biology, Biotechnology, Chemistry, Physics, Biophysics, Geology, Astronomy, Mathematics, Statistics), Pharmaceutical Sciences, Engineering and Technology, Medicine, Dentistry, Veterinary medicine, Agricultural Sciences.</p>http://www.jisciences.com/index.php/journal/article/view/95Formulation development and evaluation of bilayered tablets of amlodipine as immediate release layer and metaclopromide as sustained release layer2025-01-29T00:30:31-05:00Vinod Kumar Ksaappublications@gmail.comThangabalan Bsaappublications@gmail.comSaidu Hussaian Dudekulasaappublications@gmail.com<p>In the present study an attempt was made to prepare bilayer tablets of Amlodipine Besylate and Metoclopromide Succinate sustained release layer, which remains in stomach for prolonged period of time in a view to maximize bioavailability of drug, by using various concentrations of polymers, fifteen formulations of Metoclopromide having polymers at different concentration levels were prepared of which three formulations F8, F10, F13 showed excellent drug release profiles so these formulations were selected for the preparation of bilayer floating tablets. Amlodipine Besylate layer (immediate release) A1 was prepared by using sodium starch glycolate as super disintegrant, which showed excellent drug release so the composition of immediate release layer is kept constant in all formulations. Best formulations from both the layers were selected and formulated as bilayer tablets i.e (A1+F8), (A1+F10), (A1+F13) and these formulationsshowed excellent post compression C invitro drug release, hence all the three formulations were selected asoptimized formulations.</p>2024-12-31T00:00:00-05:00Copyright (c) 2024 http://www.jisciences.com/index.php/journal/article/view/92Digital transformation and industry 4.0 in pharma manufacturing: the role of iot, ai, and big data2024-11-11T01:57:05-05:00Sanket J Sonisanket45.com@gmail.comAnkitkumar N Patelsanket45.com@gmail.com<p>The pharmaceutical industry is undergoing a significant transformation driven by the integration of digital technologies, collectively known as Industry 4.0. This shift is redefining how drugs are developed, manufactured, and distributed. Key technologies such as the Internet of Things (IoT), Artificial Intelligence (AI), and big data analytics are at the forefront of this change, enabling smart manufacturing, real-time process optimization, and enhanced supply chain management. IoT facilitates the creation of interconnected production environments where sensors and devices continuously monitor critical parameters, ensuring optimal conditions and predictive maintenance. AI accelerates drug discovery through predictive modeling, automates quality control processes, and employs predictive analytics to enhance maintenance and process improvement. Big data empowers data-driven decision-making, ensures regulatory compliance through comprehensive analysis, and supports the shift toward personalized medicine by enabling customized drug production. Despite the significant benefits, the adoption of these technologies poses challenges, including integration with existing systems, data security concerns, and navigating a complex regulatory landscape. This review explores these technologies' impact on pharmaceutical manufacturing, highlighting successful case studies and best practices. Additionally, it discusses the future directions, including the move towards fully autonomous systems and the importance of collaboration between tech companies, manufacturers, and regulators to drive innovation and ensure compliance. The continued evolution of digital technologies in pharma manufacturing promises to enhance efficiency, reduce costs, and deliver more personalized treatments.</p>2024-10-31T00:00:00-04:00Copyright (c) 2024