Journal of Integral Sciences

DESIGN AND OPTIMIZATION OF AIR SUSPENSION MICROENCAPSULATION PROCESS

Jameela Shaik — Tue, 16 Jun 2026 00:00:00 -0400

Microencapsulation is a versatile and well-established technology used to entrap solid, liquid, or gaseous core materials within a protective coating to enhance stability, control release, and improve handling properties. The analyzed articles collectively highlight the fundamental principles, materials, techniques, and applications of microencapsulation across pharmaceutical, food, agricultural, textile, and construction industries. Various core and coating materials, including polymers, proteins, and lipids, are discussed with emphasis on their compatibility, biodegradability, and release characteristics. The articles also address microcapsule morphology, release mechanisms, and factors influencing encapsulation efficiency. Despite its advantages, challenges such as high production costs, scalability issues, and non-uniform particle size are noted. Overall, the reviewed literature demonstrates that microencapsulation is a critical enabling technology with significant potential for innovation, especially when optimized materials and methods are selected to meet specific application requirements.

NOVEL NANO PARTICLES APPROACHES IN TRAGETED THERAPY OF BRAIN CANCER

Karim Basha Shaik — Thu, 11 Jun 2026 00:00:00 -0400

Brain cancer, particularly glioblastoma, remains one of the most aggressive and difficult-to-treat malignancies due to the restrictive nature of the blood–brain barrier (BBB) and blood–brain–tumour barrier (BBTB). The reviewed articles collectively highlight the transformative role of nanotechnology in improving the diagnosis, imaging, and treatment of brain tumours. Nanoparticles (NPs), including lipid-based, polymeric, metallic, carbon-based, virus-based, and biomimetic nanomaterials, demonstrate enhanced permeability, targeted delivery, and multifunctional capabilities. Their nanoscale size, high surface area, and modifiable surfaces enable efficient BBB penetration, tumour-specific targeting, drug encapsulation, and controlled release. In addition to therapeutic applications, nanostructures offer optical, magnetic, and photodynamic properties that significantly enhance imaging precision and multimodal diagnostics. While nanotechnology presents substantial clinical promise, concerns regarding neurotoxicity and long-term. safety necessitate standardized toxicological evaluation. Current research emphasizes improving specificity, minimizing adverse effects, and developing biocompatible and cell membrane-coated systems for safer clinical translation. Overall, nanotechnology-based platforms represent a rapidly advancing strategy that integrates targeted therapy and advanced imaging, offering improved efficacy and potential breakthroughs in brain cancer management while underscoring the importance of safety optimization.

ORGAN ON A CHIP INNOVATION IN PRECISION MEDICINE AND DRUG DESIGN

Reshma Shaik — Tue, 16 Jun 2026 00:00:00 -0400

Organ-on-a-chip (OOC) technology is an advanced microengineered system that recreates the structure and function of human organs on a small, chip-based platform. By combining cell biology, biomaterials, engineering, and microfluidics, these devices imitate the natural environment of tissues, including fluid flow, mechanical forces, and cell interactions. Unlike traditional 2D cell cultures and animal testing, OOC systems provide more realistic physiological conditions while reducing cost and ethical concerns.Various organ models such as lung, liver, kidney, heart, intestine, skin, and brain have been successfully developed. These systems are widely used in drug screening, toxicology studies, disease modeling, pharmacokinetics, and personalized medicine research.

THERAPEUTIC POTENTIAL OF PHYTO CHEMICALS IN DIABETES CARE

David Kery Sikha — Tue, 16 Jun 2026 00:00:00 -0400

The Therapeutic possibilities of plant based treatments the management of diabetetes of mechanism of the action. Diabetes mellitus is a common chronic Illness that serious danger at around the entire world. the properties of following plants are Alstonia scholaris, Annona squamosa, momordica charantia, cinnamon, fenugreek, Allium sativum, Neem, Ocimum sanctum, Ginseng berry, Aloe vera this data process are identify potiential phytoconstituents for treatment of diabetes mellitus.Herbal drugs are controlling diabetes safely effectively and different methods of action experiments on animals and humans. This review important discoveries and medicinal uses herbal treatment for diabetes WHO acknowledges the potiential of herbal drugs in treating different health issues, such as diabetes utilized conventional therapies. It is important to emphasize that herbal treatments are displayed potential diabetes they should be healthcare experts.herbal remedies have been traditionally treat to diabetes.the parts used test models hypoglycaemic [blood-sugar-lowering] active compounds of 20 plant species for 12 families crucial role of plant diabetes. The plants can delay complications from diabetes and metabolic imbalance.This review can attempt to cover for herbal plants like melon, fenugreek, ginseng cinnamon, garlic, gymnema managing blood glucose level due to saponin, terpenoids,flavonoids useful controlling diabetes descrption of gymnema gurmarin possible mechanism the gumarin helps manage taste buds receptors TIR1,TIR3 both β-cells and islets, PPARγ (peroxisome proliferator activated receptor gamma) β-cells is stimulated by gymnema. Plant culture methods gymnemic acid production Diabetes mellitus affecting over 537 million people poses health challenges prevalence and complications like Neuropathy, cardiovascular sylvestre, momordica charantia, trigonella, foenum-graecum cinnamomum veum, Aloe vera and clinical efficacy through results vary due to standardization issues.

HE POWDER OF PLANTS: EXPLORING HERBAL NUTRACUETICLES

Uma Shankar Some — Wed, 17 Jun 2026 00:00:00 -0400

Nutraceuticals are bioactive compounds derived from food sources that provide health benefits beyond basic nutrition. This seminar report presents an extensive overview of nutraceuticals, including their definition, classification, advantages, bioactive components, probiotics, safety considerations, regulatory frameworks, and future prospects. The increasing prevalence of lifestyle-related disorders has created demand for preventive healthcare strategies, where nutraceuticals play a vital role. Functional foods, dietary supplements, antioxidants, and probiotic-based products contribute to maintaining physiological balance and improving quality of life. Advances in nanotechnology, nutrigenomics, and microbiome research are shaping the future of nutraceutical development. This report highlights the importance of scientific validation, quality control, and standardized regulatory practices to ensure safety and efficacy in modern healthcare.