FORMULATION AND EVALUATION OF A NATURAL EXCIPIENT–BASED ANTIFUNGAL GEL CONTAINING CLOTRIMAZOLE FOR TOPICAL APPLICATION

Sushma K; Rajender Reddy Karnekanti; Teja Kumar Reddy Konatham

doi:10.37022/jis.v9i1.130

K. Sushma Assistant Professor, Department of Pharmaceutics, School of Pharmacy, Parul University, P.O. Limda, Ta. Waghodia -391760, Dist. Vadodara,Gujarat (India)
Rajender Reddy Karnekanti Lecturer in Chemistry, Department of Sciences and Humanities, Government Polytechnic Parkal, Hanamkonda, Telangana -506164
Konatham Teja Kumar Reddy Associate Professor, Department of Pharmaceutical Analysis, Malla Reddy Institute of Pharmaceutical Sciences, Malla Reddy Vishwavidyapeeth (Deemed to be University) , Secunderabad, 500100, Telangana.

DOI https://doi.org/10.37022/jis.v9i1.130

Abstract

Clotrimazole is a widely used imidazole antifungal agent effective against dermatophytes, yeasts, and molds; however, conventional topical formulations often suffer from poor patient compliance and limited residence time at the site of action. The present study aimed to formulate and evaluate a topical antifungal gel of clotrimazole using a combination of natural and synthetic excipients to enhance safety, spreadability, and drug release. Gels were prepared using natural gelling agents such as tragacanth and gelatin, along with polyethylene glycol 400, glycerin, aloe vera, vitamin E, and benzoic acid as a preservative. The formulations were evaluated for physicochemical properties including pH, spreadability, viscosity, washability, homogeneity, drug content, and in vitro drug release using simulated vaginal fluid. Among the prepared formulations, batch F2 demonstrated optimal spreadability, acceptable viscosity, and superior drug release characteristics. The results indicate that clotrimazole gel formulated with natural excipients can serve as a safe, effective, and patient-friendly topical antifungal delivery system.

Keywords: Clotrimazole, Topical antifungal gel, Natural excipients, Drug release study,, Spreadability and viscosity, Simulated vaginal fluid

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