Nano Medicine for Ocular Drug Delivery

Sudha Kiranmai Karicharla

doi:10.37022/jis.v8i2.105

Karicharla Sudha Kiranmai Priyadarshini Institute of Pharmaceutical Education and Research-5thMile, Pulladigunta, Guntur-522017 Andhra Pradesh, India

DOI https://doi.org/10.37022/jis.v8i2.105

Abstract

Nano emulsions are considered as the most promising solution to improve the delivery of ophthalmic drugs. The design of ophthalmic nano emulsions requires an extensive understanding of pharmaceutical as well as technological aspects related to the selection of excipients and formulation processes. Nano emulsions are liquid-in-liquid dispersion with a droplet size of about 100 nm. They have a transparent appearance, high rate of bioavailability, and increased shelf life. Nano emulsions mainly consist of oil, water, surfactant, and cosurfactant and can be prepared by high- and low-energy methods. These nano emulsions are subjected to certain tests, such as safety, stability, pH profile, rheological studies, and so on. . This review focuses on nano technology-based eye disease treatment systems and highlights the obstacles affecting the drug management of eyes and nano-systems for the treatment of eye diseases. This paper summarizes the development prospect of nanotechnology and the challenges it faces in the treatment and diagnosis of ophthalmic diseases, to provide information and new ideas for the implementation of treatment and the development of a refractory eye disease management system. Ocular drug delivery has constantly challenged ophthalmologists and drug delivery scientists due to various ana tomical and physiological barriers. . State-of-the-art nano-formulations are currently being examined for their possible beneficial effects in diagnosing and treating various nervous-related ocular conditions. This review article summarizes the main characteristics of nano emulsions, ophthalmic nano emulsions, and cationic nano emulsions and their components, methods of preparation, and the evaluation parameters for ophthalmic nano emulsions

Keywords: Nano Emulsion, Ophthalmic Nano Emulsion, Ophthalmic Formulations

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