Assessment of numerous novel peptidomimetics
Abstract
Because of the availability of massive amounts of genomic and proteomic data, peptides have great pharmaceutical potential as active drugs and diagnostics in a variety of clinical areas such as endocrinology, urology, obstetrics, oncology, and so on, as well as as functional to overcome tissue and cellular membrane barriers, excipients are used in drug delivery systems. The importance of peptidomimetics in molecular recognition and signaling, particularly in living systems, drives their design and synthesis. Peptidomimetics can be designed from a variety of angles, and they can be classified in a variety of ways. According to a review of the literature, medicinal and organic chemists who work with peptide mimics use these methods in various ways. This manuscript is an attempt to discuss a variety of methodologies and strategies for developing and establishing systematic tools for the transformation of peptides into peptidomimetics or further into small drug-like molecules and their pharmacological activities relevant to modern drug design.
Keywords:
Peptidomimetics, active drugs, obstetrics, oncology, endocrinology, urology
References
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23. Uppugalla S, Boddula R, Srinivasan P. Methyl triphenylphosphonium permanganate as a novel oxidant for aniline to polyaniline-manganese (II, IV) oxide: material for high performance pseudocapacitor. Journal of Solid State Electrochemistry. 2018 Feb;22(2):407-15.
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26. Ruzza P,Calderan A. Radiolabeled peptide-receptor ligands in tumor imaging Expert Opin. Med Diagn.2011; 5(5): 411-424.
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28. CEYDA etal., design & synthesis of novel peptidomimetics for cancer immunotherapy. JOURNAL 1802 Organic Communications VOLUME & ISSUE, Year: 2020 Issue: 3 July-September PAGES p.89 – 102
29. Jiawei Chen , Qiaoli Lv , Guogang Tu. Synthesis and Molecular Simulation Studies of Mandelic Acid Peptidomimetic Derivatives as Aminopeptidase N Inhibitors 2021;17(5):619-626. doi: 10.2174/1573409916666200703161039.
30. J. Brango-Vanegas, Luan A. Martinho, L. J. Bessa, A. G. Vasconcelos, Alexandra Plácido, A. L. Pereira, J. Leite, A. H. Machado. Synthesis of novel sulfide-based cyclic peptidomimetic analogues to solonamides, Published 25 October 2019Chemistry, Biology, Beilstein Journal of Organic Chemistry
31. Martin McLaughlin, Ryo Yazaki, Thomas C. Fessard, and Erick M. Carreira. Oxetanyl Peptides: Novel Peptidomimetic Modules for Medicinal Chemistry Publication Date:July28, 2014 https://doi.org/10.1021/ol501590n
2. Roh, J.D., Kitchen, R.R., Guseh, J.S., McNeill, J.N., Aid, M., Martinot, A.J., Yu, A., Platt, C., Rhee, J., Weber, B. and Trager, L.E., 2022. Plasma proteomics of COVID-19–associated cardiovascular complications: implications for pathophysiology and therapeutics. Basic to Translational Science, 7(5), pp.425-441.
3. Boini, K.M., singh, A. and Koka, S.S., 2021. Gut Microbial Metabolite Trimethylamine N-oxide Enhances Endoplasmic Reticular Stress and Promotes Endothelial Dysfunction. Circulation, 144(Suppl_1), pp.A14071-A14071.
4. Roh, J., Hill, J.A., Singh, A., Valero-Muñoz, M. and Sam, F., 2022. Heart failure with preserved ejection fraction: heterogeneous syndrome, diverse preclinical models. Circulation Research, 130(12), pp.1906-1925.
5. Ginj M , Zhang HW, Waser B, Cescato R, Wild D, Wang XJ, Erchegyi J, Rivier J, Macke HR, Reubi JC. Radiolabeled somatostatin receptor antagonists are preferable to agonists for in vivo peptide receptor targeting of tumors. Proc Natl Acad Sci. U. S. A.2008;103(44): 16436-16441.6.
6. Singh, A., Srinivasan, A.K., Chakrapani, L.N. and Kalaiselvi, P., 2019. LOX-1, the common therapeutic target in hypercholesterolemia: a new perspective of antiatherosclerotic action of aegeline. Oxidative medicine and cellular longevity, 2019.
7. Singh, A., Gowtham, S., Chakrapani, L.N., Ashokkumar, S., Kumar, S.K., Prema, V., Bhavani, R.D., Mohan, T. and Sathyamoorthy, Y.K., 2018. Aegeline vs Statin in the treatment of Hypercholesterolemia: A comprehensive study in rat model of liver steatosis. Functional Foods in Health and Disease, 8(1), pp.1-16.
8. Singh, A., Kumar, A. and Kalaiselvi, P., 2018. Aegeline, targets LOX1, the receptor for oxidized LDL to mitigate hypercholesterolemia: a new perspective in its anti-atherosclerotic action. Free Radical Biology and Medicine, 128, p.S41.
9. Abhilasha, S., Narasimhan, C.L., Kumar, S.A., Kumar, S.N.K., Bhavani, R.D., Thangarajeswari, M., Prema, V. and Kalaiselvi, P., 2017. Ethanolic extract of aegle marmelos mediates its hypocholesterolemic effect by retarding circulatory oxidized ldl formation via 12/15 lipoxygenase pathway.
10. Singh, A., 2022. Role of microbial metabolites in cardiovascular and human health. In Microbiome, Immunity, Digestive Health and Nutrition (pp. 137-148). Academic Press.
11. Singh, A., 2022. Role of microbial metabolites in cardiovascular and human health. In Microbiome, Immunity, Digestive Health and Nutrition (pp. 137-148). Academic Press.
12. Shiv Chandra Singh, A., Yu, A., Chang, B., Li, H., Rosenzweig, A. and Roh, J.D., 2021. Exercise Training Attenuates Activin Type II Receptor Signaling in the Aged Heart. Circulation, 144(Suppl_1), pp.A14259-A14259.
13. Cudic P, Stawikowski M. Pseudopeptide synthesis via Fmoc solid-phase synthetic methodology Mini-Rev.Org Chem.2007; 4( 4):268-280
14. Li, SSC. Specificity and versatility of SH3 and other proline-recognition domains: structural basis andimplications for cellular signaltransduction. Biochem J.2005;390:641-653.
15. Marchiani A, Antolini N, Calderan A, Ruzza P. Atypical SH3 domain binding motifs: features and properties .Curr Top Pept.2009;10: 45-56
16. Mayer BJ, Hamaguchi M, Hanafusa H. A novel viral oncogene with structural similarity to phospholipase C. Nature,1988; 332 :272-275.
17. Merrifield RB. Solid-Phase Peptide Synthesis. In: Advances in Enzymology and Related Areas of MolecularBiology.2006: 221-296.
18. Nestor JJ, Jr.The medicinal chemistry of peptides. Curr Med Chem.2009; 16( 33):4399- 4418.
19. Uppugalla S, Male U, Srinivasan P. Design and synthesis of heteroatoms doped carbon/polyaniline hybrid material for high performance electrode in supercapacitor application. Electrochimica Acta. 2014 Nov 10;146:242-8.
20. Male U, Uppugalla S, Srinivasan P. Effect of reduced graphene oxide–silica composite in polyaniline: electrode material for high-performance supercapacitor. Journal of Solid State Electrochemistry. 2015 Nov;19(11):3381-8.
21. Uppugalla S, Srinivasan P. High-performance supercapacitor coin cell: polyaniline and nitrogen, sulfur-doped activated carbon electrodes in aqueous electrolyte. Journal of Solid State Electrochemistry. 2019 Jan;23(1):295-306.
22. Uppugalla S, Srinivasan P. Polyaniline nanofibers and porous Ni [OH] 2 sheets coated carbon fabric for high performance super capacitor. Journal of Applied Polymer Science. 2019 Nov 5;136(41):48042.
23. Uppugalla S, Boddula R, Srinivasan P. Methyl triphenylphosphonium permanganate as a novel oxidant for aniline to polyaniline-manganese (II, IV) oxide: material for high performance pseudocapacitor. Journal of Solid State Electrochemistry. 2018 Feb;22(2):407-15.
24. Reubi JC, Gugger M, Waser B. Co-expressed peptide receptors in breast cancer as a molecular basis for in vivo multireceptor tumour targeting. Eur J Nucl Med Mol Imaging.2002; 29(7) :855-862.
25. Rufini V, Calcagni ML, Baum RP. Imaging of neuroendocrine tumors Semin. Nucl Med.2006; 36(3): 228-247.
26. Ruzza P,Calderan A. Radiolabeled peptide-receptor ligands in tumor imaging Expert Opin. Med Diagn.2011; 5(5): 411-424.
27. Ruzza P, Donella-Deana A, Calderan A, Brunati A, Massimino M.L, Elardo S, Mattiazzo A, Pinna LA, Borin G. Antennapedia/HS1 chimeric phosphotyrosyl peptide: Conformational properties binding capability to c-Fgr SH2 domain and cell permeability. Biopolymers.2001; 60(4): 290-306.
28. CEYDA etal., design & synthesis of novel peptidomimetics for cancer immunotherapy. JOURNAL 1802 Organic Communications VOLUME & ISSUE, Year: 2020 Issue: 3 July-September PAGES p.89 – 102
29. Jiawei Chen , Qiaoli Lv , Guogang Tu. Synthesis and Molecular Simulation Studies of Mandelic Acid Peptidomimetic Derivatives as Aminopeptidase N Inhibitors 2021;17(5):619-626. doi: 10.2174/1573409916666200703161039.
30. J. Brango-Vanegas, Luan A. Martinho, L. J. Bessa, A. G. Vasconcelos, Alexandra Plácido, A. L. Pereira, J. Leite, A. H. Machado. Synthesis of novel sulfide-based cyclic peptidomimetic analogues to solonamides, Published 25 October 2019Chemistry, Biology, Beilstein Journal of Organic Chemistry
31. Martin McLaughlin, Ryo Yazaki, Thomas C. Fessard, and Erick M. Carreira. Oxetanyl Peptides: Novel Peptidomimetic Modules for Medicinal Chemistry Publication Date:July28, 2014 https://doi.org/10.1021/ol501590n
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Sidde, L., C, A., S, R. P., D, V. R., & C, M. (2022). Assessment of numerous novel peptidomimetics. Journal of Integral Sciences, 5(2), 1-8. Retrieved from https://www.jisciences.com/index.php/journal/article/view/33
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